Eugena Chang joined the cello section of the National Symphony Orchestra in 2016. Prior to her appointment with the NSO, she was a member of the Minnesota Orchestra, since 2007, when she graduated from the Curtis Institute of Music after studying with Orlando Cole, Peter Wiley, and William Stokking, and serving as principal cello of the Curtis Orchestra. Chang attended Itzhak Perlman's summer music program from 2002-2006, studying there with Ron Leonard and Paul Katz, and she has also studied with Eleonore Schoenfeld. She has performed as soloist with the Warminster Symphony Orchestra, Pottstown Symphony, National Repertory Orchestra, and Kenneth Symphony.

As the recipient of numerous awards, prizes, and scholarships, Chang has appeared across the nation as a recitalist and chamber musician, and several of her performances have been broadcast on radio and television. In 2009, she made her Paris recital debut at the Auditorium du Louvre.